TRASTUZUMAB AND PERTUZUMAB NO FURTHER A MYSTERY

The phosphorylated HER3 supplies docking web-sites for p85 subunit of PI3K. The thoroughly activated PI3K complex is created by binding of p110 subunit of PI3K to p85 which can develop PIP3 by way of phosphorylating the PIP2. AKT binds to PIP3 and it is phosphorylated by PDK1 and mTORC2. Phosphorylation of AKT at each threonine and serin phosphoryl